Our group is interested in:

  1. developing synthetic methodologies, strategies and their applications in natural product total synthesis;
  2. devising novel multicomponent reactions (MCRs) and metal-catalyzed domino processes for the rapid construction of medicinally relevant heterocycles and macrocycles;
  3. searching for new catalytic enantioselective transformations, particularly enantioselective MCRs;
  4. Designing and synthesizing small molecules with specific biological activities.

Latest News

February 2019 :  Warm welcome to our new intern Dan Forster ! Best of luck with your chemistry !

February 2019 : Hua’s review on catalytic enantioselective rearrangements has been highlighted as a very important paper in Eur. JOC ! Congratulations !

January 2019 : Congratulations to Jacobus & Xu for their new publication in Helvetica Chimica Acta : “Formal[4+1] Cycloaddition of o-Aminobenzyl Chlorideswith Isocyanides: Synthesis of 2-Amino-3-Substituted Indoles”

January 2019 : Congratulations to Xu for his recent publication in Angewandte : “Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts”

January 2019 : Congratulations to Guang & Cyril for their recent publication in Angewandte : “Stereoselective Total Synthesis of Eburnane-type Alkaloids Enabled byConformation-Directed Cyclization and Rearrangement

December 2018 : Congratulations to Mathias for receiving the “Teaching Excellence Award” in recognition of his contribution to the education.

December 2018 : Congratulations to Qiu, Charlotte, David and Sheng-Cai for their recent paper in Tetrahedron : “From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of allyl carbonate by α-isocyanoacetate

December 2018 : Congratulations to Sheng-Cai whose paper was accepted in Angewandte “Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles” !

November 2018 : Congratulation to Nicolas Gaeng for the successful defense of his PhD thesis.

November 2018 : Congratulations to Hua & Rémi for their publication in Angewandte “Catalytic Enantioselective α‐Ketol Rearrangement” !

October 2018 : Welcome to Dina & Rémi, our new PhD students ! Best of luck with your new projects !

September 2018 : Congratulations to Xu, Takayuki and Tu for their recent publication in Nature Communications “Copper-catalyzed methylative difunctionalization of alkenes” !!

September 2018 : Zhaodong’s paper entitled “Copper-Catalyzed Remote C(sp3)-H Arylation of Carboxamides and Sulfonamides” was accepted in Angew Chem. Congratulations!

September 2018 : Zhengren’s review entitled: “Metamorphosis of Cycloalkenes for the Divergent Total Synthesis of Polycyclic Indole Alkaloids” was accepted in Chem. Soc. Rev. Congratulations!

August 2018 : GoodBye to Angel, who stayed one year with us as a PhD Exchange ; he will now return to Mexico to complete his PhD. Good luck !

July 2018 : Welcome to Prof. Zhang Fengzhi, new visiting professor in our group ! Enjoy your stay in Switzerland.

July 2018 : Welcome to Nicoleta, our new summer intern !

July 2018 : Jieping’s and Wangqing’s minireview on the “Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions” is now online on Angewandte.

June 2018 : Shuo’s paper entitled “Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines” was accepted in Tetrahedron. It will be published in a special issue dedicated to the memory of Prof. Sir. Derek H. Barton. Congratulations !

June 2018 : Omar’s paper entitled “Total Synthesis of (+)-Hinckdentine A” was highlighted in Synfacts. Congratulations!

May 2018 : Welcome to Junpei, our new PhD exchange student coming straight from Japan ! Best of luck with your total synthesis !

May 2018 : Qian’s and Jieping’s review on enantioselective MCRs was just published in Accounts of Chemical Research.

April 2018 : Omar’s total synthesis of (+)-Hinckdentine A was just published in Angewandte. Congratulations !

Latest Publications

Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts

Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201813356)

Formal[4+1] Cycloaddition of o-Aminobenzyl Chlorideswith Isocyanides: Synthesis of 2-Amino-3-Substituted Indoles

Jacobus A. W. Jong, Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu

in Helv. Chim. Acta, 2019, ASAP (DOI : 10.1002/hlca.201900002)

Stereoselective Total Synthesis of Eburnane-type Alkaloids Enabled byConformation-Directed Cyclization and Rearrangement

Dr. Guang Li, Dr. Cyril Piemontesi, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2018, ASAP (DOI: doi.org/10.1002/anie.201813920)

From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of allyl carbonate by α-isocyanoacetate

Dr. Guanyinsheng Qiu, Charlotte Sornay, David Savary, Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Tetrahedron, 2018, 74 (49), 6966-6971 (DOI : doi.org/10.1016/j.tet.2018.10.032)

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles

Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.201812654 )

Catalytic Enantioselective α‐Ketol Rearrangement

Dr. Hua Wu, Rémi Andres, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201812244 )

Copper-catalyzed methylative difunctionalization of alkenes

Dr. Xu Bao, Dr. Takayuki Yokoe, Dr. Tu M. Ha, Dr. Qian Wang, and Prof. Jieping Zhu

in Nature Communications, ASAP (DOI : 10.1038/s41467-018-06246-6)

Copper‐Catalyzed Arylation of Remote C(sp3)−H Bonds in Carboxamides and Sulfonamides

Dr. Zhaodong Li, Dr. Qian Wang, and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201807623 )

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Dr. Zhengren Xu, Dr. Qian Wang and Prof. Jieping Zhu

in Chem. Soc. Rev., ASAP ( DOI : 10.1039/c8cs00454d )

Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

Yuanyuan Ping, Yuxiu Li, Prof. Jieping Zhu and Prof. ​​​​​​​Wangqing Kong

in Angewandte, ASAP (DOI : 10.1002/anie.201806088 )

Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines

Dr. Shuo Tong, Dr. Qian Wang, Prof. Mei-Xiang Wang, Prof. Jieping Zhu

in Tetrahedron, 2018, 74 (38), 5143-5149. (DOI : 10.1016/j.tet.2018.05.055)

Still Unconquered: Enantioselective Passerini and Ugi Multicomponent Reactions

Dr. Qian Wang, Prof. Dr. De-Xian Wang , Prof. Dr. Mei-Xiang Wang , and Prof. Dr. Jieping Zhu

in Acc. Chem. Res., ASAP. (DOI: 10.1021/acs.accounts.8b00105)

Heteroannulation of Arynes with α‐Amino Imides: Synthesis of 2,2‐Disubstituted Indolin‐3-ones and Application to the Enantioselective Total Synthesis of (+)‐Hinckdentine A

Dr. Rubén O. Torres‐Ochoa, Dr. Thomas Buyck, Dr. Qian Wang, Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2018, ASAP. (DOI: 10.1002/anie.201800746)

Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts

Dr. Hua Wu, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2018, ASAP. (DOI: 10.1002/anie.201713329 )

Selected Publications