Our group is interested in:

  1. developing synthetic methodologies, strategies and their applications in natural product total synthesis;
  2. devising novel multicomponent reactions (MCRs) and metal-catalyzed domino processes for the rapid construction of medicinally relevant heterocycles and macrocycles;
  3. searching for new catalytic enantioselective transformations, particularly enantioselective MCRs;
  4. Designing and synthesizing small molecules with specific biological activities.

Latest News

October 2018 : Welcome to Dina & Rémi, our new PhD students ! Best of luck with your new projects !

September 2018 : Congratulations to Xu, Takayuki and Tu for their recent publication in Nature Communications “Copper-catalyzed methylative difunctionalization of alkenes” !!

September 2018 : Zhaodong’s paper entitled “Copper-Catalyzed Remote C(sp3)-H Arylation of Carboxamides and Sulfonamides” was accepted in Angew Chem. Congratulations!

September 2018 : Zhengren’s review entitled: “Metamorphosis of Cycloalkenes for the Divergent Total Synthesis of Polycyclic Indole Alkaloids” was accepted in Chem. Soc. Rev. Congratulations!

August 2018 : GoodBye to Angel, who stayed one year with us as a PhD Exchange ; he will now return to Mexico to complete his PhD. Good luck !

July 2018 : Welcome to Prof. Zhang Fengzhi, new visiting professor in our group ! Enjoy your stay in Switzerland.

July 2018 : Welcome to Nicoleta, our new summer intern !

July 2018 : Jieping’s and Wangqing’s minireview on the “Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions” is now online on Angewandte.

June 2018 : Shuo’s paper entitled “Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines” was accepted in Tetrahedron. It will be published in a special issue dedicated to the memory of Prof. Sir. Derek H. Barton. Congratulations !

June 2018 : Omar’s paper entitled “Total Synthesis of (+)-Hinckdentine A” was highlighted in Synfacts. Congratulations!

May 2018 : Welcome to Junpei, our new PhD exchange student coming straight from Japan ! Best of luck with your total synthesis !

May 2018 : Qian’s and Jieping’s review on enantioselective MCRs was just published in Accounts of Chemical Research.

April 2018 : Omar’s total synthesis of (+)-Hinckdentine A was just published in Angewandte. Congratulations !

April 2018 : Congratulations to Cyril, who successfully defended his PhD thesis in front of jury professors N. Cramer, J. Waser, E. M. Carreira and A. Furstner ! He will now join the Jacobsen Lab for his postdoctoral research. We all wish you the best of luck and every success for your future research !

March 2018 : Welcome to Rémi, our new master student !

February 2018 : Warmest welcome to our three new interns : Clémence, Léa and Cédric.

January 2018 : Hua’s paper on Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts was accepeted in Angewandte.  Congratulations !

Latest Publications

Copper-catalyzed methylative difunctionalization of alkenes

Dr. Xu Bao, Dr. Takayuki Yokoe, Dr. Tu M. Ha, Dr. Qian Wang, and Prof. Jieping Zhu

in Nature Communications, ASAP (DOI : 10.1038/s41467-018-06246-6)

Copper‐Catalyzed Arylation of Remote C(sp3)−H Bonds in Carboxamides and Sulfonamides

Dr. Zhaodong Li, Dr. Qian Wang, and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201807623 )

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Dr. Zhengren Xu, Dr. Qian Wang and Prof. Jieping Zhu

in Chem. Soc. Rev., ASAP ( DOI : 10.1039/c8cs00454d )

Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

Yuanyuan Ping, Yuxiu Li, Prof. Jieping Zhu and Prof. ​​​​​​​Wangqing Kong

in Angewandte, ASAP (DOI : 10.1002/anie.201806088 )

Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines

Dr. Shuo Tong, Dr. Qian Wang, Prof. Mei-Xiang Wang, Prof. Jieping Zhu

in Tetrahedron, 2018, 74 (38), 5143-5149. (DOI : 10.1016/j.tet.2018.05.055)

Still Unconquered: Enantioselective Passerini and Ugi Multicomponent Reactions

Dr. Qian Wang, Prof. Dr. De-Xian Wang , Prof. Dr. Mei-Xiang Wang , and Prof. Dr. Jieping Zhu

in Acc. Chem. Res., ASAP. (DOI: 10.1021/acs.accounts.8b00105)

Heteroannulation of Arynes with α‐Amino Imides: Synthesis of 2,2‐Disubstituted Indolin‐3-ones and Application to the Enantioselective Total Synthesis of (+)‐Hinckdentine A

Dr. Rubén O. Torres‐Ochoa, Dr. Thomas Buyck, Dr. Qian Wang, Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2018, ASAP. (DOI: 10.1002/anie.201800746)

Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts

Dr. Hua Wu, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2018, ASAP. (DOI: 10.1002/anie.201713329 )

Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (-)-Mesembrane and (+)-Crinane

Dr. Xu Bao, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2018, ASAP. (DOI: 10.1002/anie.201712521)

Cooperative Pd/Cu Catalysis: Multicomponent Synthesis of Tetrasubstituted Imidazolones from Methyl α-Isocyanoacetates, Primary Amines, and Aryl(vinyl) Iodides

Dr. Antonin Clemenceau, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Org. Lett., 2018, 20 (1), 126–129. (DOI: 10.1021/acs.orglett.7b03479)

Catalytic Enantioselective Carbopalladation/C-H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach

Dr.Shuo Tong, Aurore Limouni, Dr. Qian Wang, Prof. Dr. Mei-Xiang Wang and Prof. Dr. Jieping Zhu

in Angew. Chem. Int. Ed. 2017, 56 (45), 14192-14196. (DOI: 10.1002/anie.201709133)

Silver Nitrate-Catalyzed Isocyanide Insertion/Lactamization Sequence to Imidazolones and Quinazolin-4-ones: Development and Application in Natural Product Synthesis

Antonin Clemenceau, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Org. Lett. 2017, 19 (18), 4872-4875. (DOI: 10.1021/acs.orglett.7b02334)

Copper-Catalyzed Enantioselective Domino Arylation/Semipinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts

Dr. Hua Wu, Dr. Qian Wang and Prof. Dr. Jieping Zhu

in Chem. Eur. J. 2017, 23 (53), 13037-13041. (DOI: 10.1002/chem.201703563)

Selected Publications